Notable publications

Tissue Engineering Approaches for Musculoskeletal Tissue Regeneration

1. Kanan M, Eby O, Kelkar A, Serhan H, Zodak Y, Aldoohan S, Elsamaloty H, Goel V, Yildirim-Ayan E. Electrical Stimulation-Mediated Tissue Healing in Porcine Intervertebral Disc Under Mechanically Dynamic Organ Culture Conditions. Spine. 2022 May 15;47(10):764-72.
   
2. Subramanian G, Stasuk A, Elsaadany M, Yildirim-Ayan E. Effect of uniaxial tensile cyclic loading regimes on matrix organization and tenogenic differentiation of adipose-derived stem cells encapsulated within 3D collagen scaffolds. Stem cells international. 2017 Dec 11;2017.
3. Elsaadany M, Winters K, Adams S, Stasuk A, Ayan H, Yildirim-Ayan E. Equiaxial strain modulates adipose-derived stem cell differentiation within 3D biphasic scaffolds towards annulus fibrosus. Scientific reports. 2017 Oct 9;7(1):1-4.
4. Baawad A, Jacho D, Hamil T, Yildirim-Ayan E, Kim DS. Polysaccharide-Based Composite Scaffolds for Osteochondral and Enthesis Regeneration. Tissue Engineering. 2022 Oct 1(ja)

Biomechanical Approaches for Musculoskeletal System

1. Subramanian G, Elsaadany M, Bialorucki C, Yildirim‐Ayan E. Creating homogenous strain distribution within 3D cell‐encapsulated constructs using a simple and cost‐effective uniaxial tensile bioreactor: Design and validation study. Biotechnology and Bioengineering. 2017 Aug;114(8):1878-87.
   
2. Elsaadany M, Harris M, Yildirim-Ayan E. Design and validation of equiaxial mechanical strain platform, EQUicycler, for 3D Tissue Engineered Constructs. BioMed research international. 2017 Jan 12;2017.

Immunomodulatory approaches in musculoskeletal tissue regeneration

1. Adams S, Wuescher LM, Worth R, Yildirim-Ayan E. Mechano-immunomodulation: mechanoresponsive changes in macrophage activity and polarization. Annals of biomedical engineering. 2019 Nov;47(11):2213-31.
   

Mechanobiological Approaches in Cancer - Musculoskeletal Tissue Interaction

1. Liu R, Su S, Liu K, Xing J, Stangis M, Jacho DP, Yildirim-Ayan ED, Yu H, Chen B, Li X. Tumor removal limits prostate cancer cell dissemination in bone cortex and osteoblasts induce cancer cell dormancy. bioRxiv. 2022 Jan 1.
   

Tissue Engineering in Regenerative and Rehabilitation Medicine

1. Shortridge C, Akbari Fakhrabadi E, Wuescher LM, Worth RG, Liberatore MW, Yildirim-Ayan E. Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold. International Journal of Molecular Sciences. 2021 Jan 24;22(3):1134.
   

​Tissue Engineering in Space - Microgravity

1. Dhar S, Kaeley DK, Kanan MJ, Yildirim-Ayan E. Mechano-immunomodulation in space: Mechanisms involving microgravity-induced changes in T cells. Life. 2021 Oct 3;11(10):1043.