Patents and Intellectual Property
- Patent Number: US20110136162A1 “Compositions and methods for functionalized patterning of tissue engineering substrates including bioprinting cell-laden constructs for multicompartment tissue chambers”, Invertors: Sun, W., Snyder, J., Chang. R., Yildirim, E., Fridman, A. and Ayan, H.
- Patent Number: US 62/303,674 “Loading Platform for Three-Dimensional Tissue Engineered Scaffolds”, Invertors: Yildirim-Ayan, E., Subramanian, G., Elsaadany, M.
- Patent Number: WO2023/091640 A1 "Adjustable Gravity Simulator for Tissue and Organ Culturing", Inventors: Yildirim-Ayan, E., Ayan, Halim, and Wade Charles.
PUBLICATIONS
Journal Publications
Journal Publications
2024
1) Macrophage Mechano-Responsiveness within Three-Dimensional Tissue Matrix upon Mechanotherapy-Associated Strains
P. Babaniamansour, D. Jacho, A. Teow, A. Rabino, R. Garcia-Mata and E. Yildirim-Ayan
Tissue Engineering Part A (2024)
P. Babaniamansour, D. Jacho, A. Teow, A. Rabino, R. Garcia-Mata and E. Yildirim-Ayan
Tissue Engineering Part A (2024)
2) Modulating TRPV4 Channel Activity in Pro-Inflammatory Macrophages within the 3D Tissue Analog
P. Babaniamansour, D. Jacho, S. Niedzielski, A. Rabino, R. Garcia-Mata and E. Yildirim-Ayan
P. Babaniamansour, D. Jacho, S. Niedzielski, A. Rabino, R. Garcia-Mata and E. Yildirim-Ayan
| biomedicines-12-00230.pdf |
2023
1) Mechano-guided Strategies in Regenerative Rehabilitation
Diego Jacho and Eda Yildirim-Ayan
Current Opinion in Biomedical Engineering, 100516
Review Article
(https://www.sciencedirect.com/science/article/pii/S2468451123000727)
Diego Jacho and Eda Yildirim-Ayan
Current Opinion in Biomedical Engineering, 100516
Review Article
(https://www.sciencedirect.com/science/article/pii/S2468451123000727)
| Mechano-guided Strategies |
2) Extracellular Mechanical Stimuli Alters the Metastatic Progression of Prostate Cancer Cells within 3D Tissue Matrix
Maggie Ditto, Diego Jacho, Kathryn Eisenmann and Eda Yildirim-Ayan
Bioengineering 10 (11), 1271
Maggie Ditto, Diego Jacho, Kathryn Eisenmann and Eda Yildirim-Ayan
Bioengineering 10 (11), 1271
| extracellular_mechanical_simuli.pdf |
3) A Study on the Effect of Non-thermal Plasma on Macrophage Phenotype
Takia Sharfuddin, Diego Jacho, Dan Mitchey, Eda Yildirim-Ayan and Halim Ayan
Plasma Chemistry and Plasma Processing, 1-16
Takia Sharfuddin, Diego Jacho, Dan Mitchey, Eda Yildirim-Ayan and Halim Ayan
Plasma Chemistry and Plasma Processing, 1-16
| nonthermal_plasmaon_macrophages.pdf |
4) Macrophage Mechanoresponsiveness within 3D Tissue Matrix upon Mechanotherapy- Associated Strains
Parto Babaniamansour, Diego Jacho, Ashley Teow, Agustin Rabino, Rafael Garcia-Mata, Eda Yildirim-Ayan
Tissue Engineering Part A
https://www.liebertpub.com/doi/abs/10.1089/ten.TEA.2023.0110
Parto Babaniamansour, Diego Jacho, Ashley Teow, Agustin Rabino, Rafael Garcia-Mata, Eda Yildirim-Ayan
Tissue Engineering Part A
https://www.liebertpub.com/doi/abs/10.1089/ten.TEA.2023.0110
5) Deciphering the Cell-Specific Effect of Osteoblast-Macrophage Crosstalk in Periodontitis
Diego Jacho, Parto Babaniamansour, Raquel Osorio, Manuel Toledano, Agustín Rabino, Rafael Garcia-Mata, and Eda Yildirim-Ayan
Tissue Engineering Part A
Diego Jacho, Parto Babaniamansour, Raquel Osorio, Manuel Toledano, Agustín Rabino, Rafael Garcia-Mata, and Eda Yildirim-Ayan
Tissue Engineering Part A
| deciphering-the-cell-specific-effect-of-osteoblast-macrophage-crosstalk-in-periodontitis.pdf |
6) Tumor Removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancel cell dormancy through focal adhesion kinase
Ruihua Liu, Shang Su, Ke Liu, Jing Xing, Mary Stangis, Diego P Jacho, Eda D Yildirim-Ayan, Cara M Gatto-Weis, Haiquan Yu, Bin Chen, Xiaohong Li
Journal of Experimental and Clinical Cancer Research, 42 Article Number:264(2023)
Ruihua Liu, Shang Su, Ke Liu, Jing Xing, Mary Stangis, Diego P Jacho, Eda D Yildirim-Ayan, Cara M Gatto-Weis, Haiquan Yu, Bin Chen, Xiaohong Li
Journal of Experimental and Clinical Cancer Research, 42 Article Number:264(2023)
| tumor_removal_prostate_cancer.pdf |
7) Polysaccharide-Based Composite Scaffolds for Osteochondral and Enthesis Regeneration
Abdullah Baawad, Diego Jacho, Taijah Hamil, Eda Yildirim-Ayan, Dong-Shik Kim,
Tissue Engineering B Reviews.
https://www.liebertpub.com/doi/abs/10.1089/ten.TEB.2022.0114?journalCode=teb
Abdullah Baawad, Diego Jacho, Taijah Hamil, Eda Yildirim-Ayan, Dong-Shik Kim,
Tissue Engineering B Reviews.
https://www.liebertpub.com/doi/abs/10.1089/ten.TEB.2022.0114?journalCode=teb
2022
Evan Roebke, Diego Jacho, Oliver Eby, Sulaiman Aldoohan, Haitham Elsamaloty, Eda Yildirim-Ayan
Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study
Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study
| injectable_cell.pdf |
Jacho, D., Rabino, A., Garcia-Mata, R., Yildirim-Ayan, E.,
Scientific Reports 12
Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: mechanical strain amplitude dependency of fibrosis
Scientific Reports 12
Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: mechanical strain amplitude dependency of fibrosis
| fmt_publication.pdf |
Kanan, M., Eby, O., Kelkar, A., Serhan, H., Zodak, Y., Aldoohan, S., Elsamaloty, H., Goel, V., Yildirim-Ayan, E.,
Electrical Stimulation-Mediated Tissue Healing in Porcine Intervertebral Disc Under Mechanically Dynamic Organ Culture Conditions
Electrical Stimulation-Mediated Tissue Healing in Porcine Intervertebral Disc Under Mechanically Dynamic Organ Culture Conditions
| electrical_stimulation_mediated_tissue_healing_in.11.pdf |
2021
Patent : G Subramanian, M Elsaadany, E Yildirim-Ayan
Loading platform for three-dimensional tissue engineered scaffolds
Loading platform for three-dimensional tissue engineered scaffolds
| loading_platform.pdf |
Sarit Dhar, Dilpreet Kaur Kaeley, Mohamad Jalal Kanan, Eda Yildirim-Ayan
Mechano-immunomodulation in space: Mechanisms involving microgravity-induced changes in T cells
Mechano-immunomodulation in space: Mechanisms involving microgravity-induced changes in T cells
| mechanoimmunomodulation_in_space.pdf |
Colin Shortridge, Ehsan Akbari Fakhrabadi, Leah M Wuescher, Randall G Worth, Matthew W Liberatore, Eda Yildirim-Ayan
Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold
Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold
| impact_of_digestive_inflammatory.pdf |
2020
Surya B Karki, Tripti Thapa Gupta, Eda Yildirim-Ayan, Kathryn M Eisenmann, Halim Ayan
Miniature non-thermal plasma induced cell cycle arrest and apoptosis in lung carcinoma cells
Miniature non-thermal plasma induced cell cycle arrest and apoptosis in lung carcinoma cells
| nonthermal_plasma_induced_cell_cycle.pdf |
2019
| mechano-immunomodulation.pdf |
2004 - 2017
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Subramanian G., Stasuk A., Elsaadany M., Yildirim-Ayan E., "Effect of Uniaxial Tensile Cyclic Loading Regimes on Matrix Organization and Tenogenic Differentiation of Adipose-Derived Stem Cells Encapsulated within 3D Collagen Scaffolds", Stem Cells International, December 2017.
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Elsaadany M., Winters K., Adams S., Stasuk A., Ayan H., Yildirim-Ayan E., "Equiaxial Strain Modulates Adipose-derived Stem Cell Differentiation within 3D Biphasic Scaffolds towards Annulus Fibrosus", Scientific Reports, September 2017.
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Subramanian G., Elsaadany M., Bialorucki C., Yildirim-Ayan E.,"Creating Homogenuous strain distribution within 3D cell-encapsulated constructs using a simple and cost-effective uniaxial tensile bioreactor: design and validation study ", Biotechnology and Bioengineering, March 2017.
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Elsaadany M., Yan K., Yildirim-Ayan E.,"Predicting cell viability within tissue scaffolds under equiaxial strain: multi-scale finite element model of collagen–cardiomyocytes constructs", Biomechanics and Modeling in Mechanobiology, 2017.
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Elsaadany M., Harris M., Yildirim-Ayan E., "Design and Validation of Equiaxial Mechanical Strain Platform, EQUicycler, for 3D Tissue Engineered Constructs", BioMed Research International, Vol. 2017, 2017.
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Trumbull A., Subramanian G., Yildirim-Ayan E., "Mechanoresponsive musculoskeletal tissue differentiation of adipose‐derived stem cells", BioMedical Engineering OnLine, Vol. 15, Issue 43, 2016.
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Elsaadany M., Subramanian G., Ayan H., Yildirim-Ayan E., "Exogenous nitric oxide (NO) generated by NO-plasma treatment modulates osteoprogenitor cells early differentiation", Journal of Physics D: Applied Physics, Vol. 48, Issue 34, 2015.
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Subramanian G., Bialorucki C., Yildirim-Ayan E., "Nanofibrous yet Injectable Polycaprolactone-Collagen Bone Tissue Scaffold with Osteoprogenitor Cells and Controlled Release of Bone Morphogenetic Protein-2", Material Science and Engineering C, Vol. 51, 1 June 2015, Pages 16–27.
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Bialorucki C., Subramanian G., Elsaadany M., Yildirim-Ayan E.,"In Situ Osteoblast Mineralization Mediates Post-Injection Mechanical Properties of Osteoconductive Material", Journal of the Mechanical Behavior of Biomedical Materials, Vol. 38, 2014.
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Baylan N., Bhat S., Ditto M., Lawrence JG., Lecka‐Czernik B., Yildirim‐Ayan E., “Polycaprolactone Nanofiber Interspersed Collagen Type‐ I Scaffold for Bone Regeneration: A Unique Injectable Osteogenic Scaffold”, Biomedical Materials, Vol.8, Is. 4, 2013. (Cover Image, Featured Article, and Editor's Pick).
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Agarwal A., Palepu V., Agarwal AK., Goel VK., Yildirim-Ayan E., "Biomechanical evaluation of an endplate-conformed polycaprolactone-hydroxyapatite intervertebral fusion graft and its comparison with a typical non-conformed cortical graft”, Journal of Biomechanical Engineering, , Vol.135, Is. 6, 2013.
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Ayan H., Yildirim E.D., Pappas D., and Sun W., ”Development of a cold atmospheric pressure microplasma jet for freeform cell printing”, Applied Physics Letter, Vol 99, 2011.
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Yildirim E.D., Pappas D., Guceri S., and Sun W., “Enhanced cellular functions on polycaprolactone tissue scaffolds by O2 plasma surface modification”, Plasma Processes and Polymers, Vol.8, Issue 8, 2011.
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Yildirim E.D., Besunder R., Pappas D., Allen F., and Sun W., “Accelerated Osteoblast Differentiation on Three-Dimensional Polycaprolactone Scaffolds”, Biofabrication, Vol.2, Issue 1, 2010.
Yildirim E.D., Ayan H., Vasilets V.N., Fridman A., Guceri S., Sun W., “Effect of Dielectric Barrier Discharge Plasma on The Attachment And Proliferation of Osteoblasts Cultured over Poly (e-Caprolactone) Scaffolds”, Plasma Processes and Polymers , Vol.5, Issue 1, p:58-66, 2008.
Yildirim E.D., Yin X., Nair K., Sun W., “Fabrication, characterization and biocompatibility of single-walled carbon nanotube reinforced alginate composite scaffolds manufactured using freeform fabrication technique”, Journal of Biomedical Material Research, Vol.87B, Issue 2, p:406-414, 2008.
Yildirim E.D., Besunder R., Guceri S., Allen F., and Sun W., “Fabrication and plasma treatment of 3D Polycaprolactone Tissue Scaffolds for Enhanced Cell Functions” Virtual and Physical Prototyping, 2008, Vol.3, Issue 4, 2008.
Starly B., Yildirim E.D., Sun W., "A Tracer Metric Numerical Model for Predicting Tortuosity Factors in 3D Porous Tissue Scaffolds", Journal of Computer Methods and Programs in Biomedicine, Vol.87, Issue 1, p:21-27, 2007
Yildirim E.D., Ozerdem B., “A Numerical Simulation Study for the Human Passive Thermal System”, Energy and Buildings, Vol.40, p: 1117-1123, 2008
Yildirim E.D., Gokcen G.,“ Exergy Analysis and Performance Evaluation of Kizildere Geothermal Power Plant, Turkey”, International Journal of Exergy, Vol.1, Issue 3, 2004
Ozdamar A., Ozbalta N., Akin A., Yildirim E.D., “An Application of a Combined Wind and Solar Energy System in Izmir” Renewable and Sustainable Energy Reviews, Vol.9, Issue 6, 2005.
Journal Publications in Preparation
Ditto M., Eisenmann KM., Yildirim‐Ayan E. "Mechanical Stimuli Mediates the Migration Potential of Prostate Cancer Cells within 3D Bone-like Environment"
Harris M., Ditto M., Bhat S., Baylan N., Yildirim-Ayan E., “Inducing Structural and Phenotypic Changes in Collagen Encapsulated Pre-Osteoblast Cells Using Novel Mechanical-strain Loading Platform”
Yildirim E.D., Ayan H., Vasilets V.N., Fridman A., Guceri S., Sun W., “Effect of Dielectric Barrier Discharge Plasma on The Attachment And Proliferation of Osteoblasts Cultured over Poly (e-Caprolactone) Scaffolds”, Plasma Processes and Polymers , Vol.5, Issue 1, p:58-66, 2008.
Yildirim E.D., Yin X., Nair K., Sun W., “Fabrication, characterization and biocompatibility of single-walled carbon nanotube reinforced alginate composite scaffolds manufactured using freeform fabrication technique”, Journal of Biomedical Material Research, Vol.87B, Issue 2, p:406-414, 2008.
Yildirim E.D., Besunder R., Guceri S., Allen F., and Sun W., “Fabrication and plasma treatment of 3D Polycaprolactone Tissue Scaffolds for Enhanced Cell Functions” Virtual and Physical Prototyping, 2008, Vol.3, Issue 4, 2008.
Starly B., Yildirim E.D., Sun W., "A Tracer Metric Numerical Model for Predicting Tortuosity Factors in 3D Porous Tissue Scaffolds", Journal of Computer Methods and Programs in Biomedicine, Vol.87, Issue 1, p:21-27, 2007
Yildirim E.D., Ozerdem B., “A Numerical Simulation Study for the Human Passive Thermal System”, Energy and Buildings, Vol.40, p: 1117-1123, 2008
Yildirim E.D., Gokcen G.,“ Exergy Analysis and Performance Evaluation of Kizildere Geothermal Power Plant, Turkey”, International Journal of Exergy, Vol.1, Issue 3, 2004
Ozdamar A., Ozbalta N., Akin A., Yildirim E.D., “An Application of a Combined Wind and Solar Energy System in Izmir” Renewable and Sustainable Energy Reviews, Vol.9, Issue 6, 2005.
Journal Publications in Preparation
Ditto M., Eisenmann KM., Yildirim‐Ayan E. "Mechanical Stimuli Mediates the Migration Potential of Prostate Cancer Cells within 3D Bone-like Environment"
Harris M., Ditto M., Bhat S., Baylan N., Yildirim-Ayan E., “Inducing Structural and Phenotypic Changes in Collagen Encapsulated Pre-Osteoblast Cells Using Novel Mechanical-strain Loading Platform”
Conference Proceedings (selected)
Subramanian G., Yildirim‐Ayan E., “Effect of Mechanical Loading on Matrix Alignment and Tenogenic Differentiation of Adipose-derived Stem Cells Encapsulated within a Three-dimensional Collagen Construct”. ORS, March 5-8, 2016, Orlando, FL. (Oral presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cell Damage within Musculoskeletal Tissue Scaffold under Equiaxial Strain using Multi-length Scale Finite Element Model”. ORS, March 5-8, 2016, Orlando, FL. (Poster presentation)
Subramanian G., Yildirim‐Ayan E., “Effect of Uniaxial Mechanical Strain on Tenogenic Differentiation of Adipose-derived Stem Cells within Collagen Constructs”. Midwest Biomedical Engineering Society Career Conference, November 6, 2015, The University of Akron, OH. (Poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cardiomyocytes Viability within Collagen Scaffold under Equiaxial Strain: Multi-scale Finite Element Analysis”. Midwest Biomedical Engineering Society Career Conference, November 6, 2015, The University of Akron, OH. (Poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cell Damage using Multiscale Finite Element Modelling of 3D Cell-embedded Collagen Constructs under Equiaxial Strain”. Tissue Engineering and Regenerative Medicine International Society- World Congress, September 8-11, 2015, Boston, MA. (Abstract accepted for poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Multi-scale finite element modelling of 3D cell-embedded collagen constructs under equiaxial strain”. Midwest American Society of Biomechanics Regional meeting, March 4-5, 2015, The University of Akron, OH. (Oral presentation)
Elsaadany M., Subramanian G., Ayan H., Yildirim-Ayan E., “Exogenous Nitric Oxide Production Using Dielectric Barrier Discharge Plasma for Enhanced Osteoblasts Activity”. Biomedical Engineering Society, October 22-25, 2014, San Antonio, TX. (Oral presentation)
Subramanian G., Bialorucki C.., Yildirim‐Ayan E., “Injectable and Biomimetic Polycaprolactone-Collagen Orthobiologic Scaffold for Minimally-invasive Bone Fracture Augmentation”. Midwest Graduate Research Symposium, March 29, 2014, The University of Toledo, OH. (Poster presentation-Best Poster Award)
Elsaadany M., Subramanian G., Ayan H., Yildirim-Ayan E., “Exogenous Nitric Oxide Production Using Dielectric Barrier Discharge Plasma for Enhanced Osteoblasts Activity”. Midwest Graduate Research Symposium, March 29, 2014, The University of Toledo, OH. (Poster presentation)
Bialorucki C., Subramanian G., Elsaadany M., Yildirim‐Ayan E., “In Situ Mineralization Mediates Mechanical Properties of an Injectable Cell-Instructive Material”. Orthopedic Research Society, March 15-18, 2014, New Orleans, LA. (Poster presentation)
Subramanian G., Bialorucki C.., Yildirim‐Ayan E., “Injectable and Biomimetic Polycaprolactone-Collagen Orthobiologic Scaffold For Minimally-invasive Bone Fracture Augmentation”. Orthopedic Research Society, March 15-18, 2014, New Orleans, LA. (Poster presentation)
Subramanian G., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Nanofibrous Polycaprolactone (PCL)/ Collagen Bone Augmentation Material for Irregular Shape Bone Defects”. Tissue Engineering and Regenerative Medicine International Society- Europe, June 17-20, 2013, Istanbul, Turkey. (Abstract accepted for poster-talk presentation)
Subramanian G., Elsaadany M., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Biomimetic, Nanofibrous Orthobiologic Scaffold for Minimally-Invasive Bone Fracture Augmentation”. International Symposium on Grand Challenges for the Integration of Stem Cells, Nanomaterials and Biomanufacturing, June 3-4, 2013, Shanghai, China. (Oral presentation by Dr. Yildirim-Ayan)
Subramanian G., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Nanofibrous Polycaprolactone (PCL)/ Collagen Bone Augmentation Material for Irregular Shape Bone Defects”. Northeast Ohio Musculoskeletal Research Retreat: April 6, 2013, Case Western Reserve University, OH. (Poster presentation-Best Poster Award)
Ditto M., Harris M., Eisenmann K., Yildirim‐Ayan E. "Force-induced strain mediated prostrate cancer cell and collagen alignment in three-dimensional environment". Biomedical Engineering Society, October 24-27, 2012, Atlanta, GA. (Poster presentation)
Baylan N., Bhat S., Ditto M., Lawrence JG., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Polycaprolactone Nanofibers Interspersed-Collagen Scaffold (P-NCOL) for Improved MC3T3-E1 Osteogenic Activity” Biomedical Engineering Society, October 24-27, 2012, Atlanta, GA. (Poster presentation)
Baylan N., Bhat S., Ditto M., Lawrence JG., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Polycaprolactone Nanofibers Interspersed-Collagen Scaffold (P-NCOL) for Improved MC3T3-E1 Osteogenic Activity” International Conference on Tissue Science and Engineering, October 1-3, 2012 Chicago, IL.
Harris M., and Yildirim E.D., “A Method for Aligning Cells and Applying Homogenous Tensile Strain in Collagen Gels” , Tissue Engineering International & Regenerative Medicine Society, December 11-14, 2011, Houston, TX. (Poster presentation)
Yildirim E.D., et.al, “Freeform Maskless Nanopatterning For Tissue Engineering Applications” Proceedings of the 1st Global Congress on NanoEngineering for Medicine and Biology (NEMB) 2010, ASME, February 7-10, 2010, Texas, USA.
Yildirim E.D., et.al, “Patterned Growth of Cells and Biomolecules using a Microplasma Printing System”, American Vacuum Society (AVS) 56th International Symposium, San Jose, CA, November 8-13, 2009.
Yildirim E.D., et.al, “Carbon Nanotube Induced Nerve Regeneration”, Conference on Translational Research and Commercialization of Nanotechnologies, Istanbul, Turkey, December 22-23, 2008.
Yildirim E.D., et.al,., “A Synergetic Contribution of Adhesive Protein Coating and Plasma Modification of Polycaprolactone Scaffolds on Osteoblast Differentiation”, Tissue Engineering and Regenerative Medicine North America, San Diego, CA, December 9, 2008.
Yildirim E.D., et.al, “Enhanced Osteoblast Function on Bone Tissue Engineering Scaffolds by Plasma Modification” the 13th International Biotechnology Symposium & Exhibition, Dalian, China, Oct. 12-17, 2008.
Yildirim E.D., et.al, “Concurrent Effect of Oxygen-based Plasma Polymerization and Fibronectin Coating of Poly e-caprolactone (PCL) Surface on Osteoblast Cell Attachment and Proliferation”, 8th World Biomaterials Congress, Amsterdam, Holland, May 28, 2008.
Yildirim E.D., et.al, “Effect of Oxygen-Radio Frequency Plasma Treatment on Three-Dimensional Poly (e-Caprolactone) Scaffolds”, Proceedings of the International Manufacturing Science and Engineering , Atlanta, Georgia, October 15-18, 2007.
Yildirim E.D., et.al, “Three Dimensional Composite Alginate/Carbon Nanotube Tissue Scaffolds Printed via Multi-Nozzle Deposition System”, Flexible Automation & Intelligent Manufacturing International Conference (FAIM), Philadelphia, PA, June 16-18, 2007.
Yildirim E.D., et.al, “Enhancement of Early-Time Points Osteoblastic Adhesion on Poly (e-Caprolactone) Scaffolds through Surface Plasma Treatment”, TERMIS North America 2007 Conference and Exposition, Westin Harbour Castle, Toronto, Canada, June 13, 2007.
Yildirim E.D., et.al, “Multi-Nozzle Deposition for Three-Dimensional Printing of Composite Alginate/Carbon Nanotube Tissue Scaffolds”, Proceedings of 17th Solid Freeform Fabrication Symposium, Austin, TX, USA, August 14-16, 2006.
Subramanian G., Yildirim‐Ayan E., “Effect of Mechanical Loading on Matrix Alignment and Tenogenic Differentiation of Adipose-derived Stem Cells Encapsulated within a Three-dimensional Collagen Construct”. ORS, March 5-8, 2016, Orlando, FL. (Oral presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cell Damage within Musculoskeletal Tissue Scaffold under Equiaxial Strain using Multi-length Scale Finite Element Model”. ORS, March 5-8, 2016, Orlando, FL. (Poster presentation)
Subramanian G., Yildirim‐Ayan E., “Effect of Uniaxial Mechanical Strain on Tenogenic Differentiation of Adipose-derived Stem Cells within Collagen Constructs”. Midwest Biomedical Engineering Society Career Conference, November 6, 2015, The University of Akron, OH. (Poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cardiomyocytes Viability within Collagen Scaffold under Equiaxial Strain: Multi-scale Finite Element Analysis”. Midwest Biomedical Engineering Society Career Conference, November 6, 2015, The University of Akron, OH. (Poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Predicting Cell Damage using Multiscale Finite Element Modelling of 3D Cell-embedded Collagen Constructs under Equiaxial Strain”. Tissue Engineering and Regenerative Medicine International Society- World Congress, September 8-11, 2015, Boston, MA. (Abstract accepted for poster presentation)
Elsaadany M., Yan K., Yildirim-Ayan E., “Multi-scale finite element modelling of 3D cell-embedded collagen constructs under equiaxial strain”. Midwest American Society of Biomechanics Regional meeting, March 4-5, 2015, The University of Akron, OH. (Oral presentation)
Elsaadany M., Subramanian G., Ayan H., Yildirim-Ayan E., “Exogenous Nitric Oxide Production Using Dielectric Barrier Discharge Plasma for Enhanced Osteoblasts Activity”. Biomedical Engineering Society, October 22-25, 2014, San Antonio, TX. (Oral presentation)
Subramanian G., Bialorucki C.., Yildirim‐Ayan E., “Injectable and Biomimetic Polycaprolactone-Collagen Orthobiologic Scaffold for Minimally-invasive Bone Fracture Augmentation”. Midwest Graduate Research Symposium, March 29, 2014, The University of Toledo, OH. (Poster presentation-Best Poster Award)
Elsaadany M., Subramanian G., Ayan H., Yildirim-Ayan E., “Exogenous Nitric Oxide Production Using Dielectric Barrier Discharge Plasma for Enhanced Osteoblasts Activity”. Midwest Graduate Research Symposium, March 29, 2014, The University of Toledo, OH. (Poster presentation)
Bialorucki C., Subramanian G., Elsaadany M., Yildirim‐Ayan E., “In Situ Mineralization Mediates Mechanical Properties of an Injectable Cell-Instructive Material”. Orthopedic Research Society, March 15-18, 2014, New Orleans, LA. (Poster presentation)
Subramanian G., Bialorucki C.., Yildirim‐Ayan E., “Injectable and Biomimetic Polycaprolactone-Collagen Orthobiologic Scaffold For Minimally-invasive Bone Fracture Augmentation”. Orthopedic Research Society, March 15-18, 2014, New Orleans, LA. (Poster presentation)
Subramanian G., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Nanofibrous Polycaprolactone (PCL)/ Collagen Bone Augmentation Material for Irregular Shape Bone Defects”. Tissue Engineering and Regenerative Medicine International Society- Europe, June 17-20, 2013, Istanbul, Turkey. (Abstract accepted for poster-talk presentation)
Subramanian G., Elsaadany M., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Biomimetic, Nanofibrous Orthobiologic Scaffold for Minimally-Invasive Bone Fracture Augmentation”. International Symposium on Grand Challenges for the Integration of Stem Cells, Nanomaterials and Biomanufacturing, June 3-4, 2013, Shanghai, China. (Oral presentation by Dr. Yildirim-Ayan)
Subramanian G., Baylan N., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Nanofibrous Polycaprolactone (PCL)/ Collagen Bone Augmentation Material for Irregular Shape Bone Defects”. Northeast Ohio Musculoskeletal Research Retreat: April 6, 2013, Case Western Reserve University, OH. (Poster presentation-Best Poster Award)
Ditto M., Harris M., Eisenmann K., Yildirim‐Ayan E. "Force-induced strain mediated prostrate cancer cell and collagen alignment in three-dimensional environment". Biomedical Engineering Society, October 24-27, 2012, Atlanta, GA. (Poster presentation)
Baylan N., Bhat S., Ditto M., Lawrence JG., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Polycaprolactone Nanofibers Interspersed-Collagen Scaffold (P-NCOL) for Improved MC3T3-E1 Osteogenic Activity” Biomedical Engineering Society, October 24-27, 2012, Atlanta, GA. (Poster presentation)
Baylan N., Bhat S., Ditto M., Lawrence JG., Lecka‐Czernik B., Yildirim‐Ayan E., “Injectable Polycaprolactone Nanofibers Interspersed-Collagen Scaffold (P-NCOL) for Improved MC3T3-E1 Osteogenic Activity” International Conference on Tissue Science and Engineering, October 1-3, 2012 Chicago, IL.
Harris M., and Yildirim E.D., “A Method for Aligning Cells and Applying Homogenous Tensile Strain in Collagen Gels” , Tissue Engineering International & Regenerative Medicine Society, December 11-14, 2011, Houston, TX. (Poster presentation)
Yildirim E.D., et.al, “Freeform Maskless Nanopatterning For Tissue Engineering Applications” Proceedings of the 1st Global Congress on NanoEngineering for Medicine and Biology (NEMB) 2010, ASME, February 7-10, 2010, Texas, USA.
Yildirim E.D., et.al, “Patterned Growth of Cells and Biomolecules using a Microplasma Printing System”, American Vacuum Society (AVS) 56th International Symposium, San Jose, CA, November 8-13, 2009.
Yildirim E.D., et.al, “Carbon Nanotube Induced Nerve Regeneration”, Conference on Translational Research and Commercialization of Nanotechnologies, Istanbul, Turkey, December 22-23, 2008.
Yildirim E.D., et.al,., “A Synergetic Contribution of Adhesive Protein Coating and Plasma Modification of Polycaprolactone Scaffolds on Osteoblast Differentiation”, Tissue Engineering and Regenerative Medicine North America, San Diego, CA, December 9, 2008.
Yildirim E.D., et.al, “Enhanced Osteoblast Function on Bone Tissue Engineering Scaffolds by Plasma Modification” the 13th International Biotechnology Symposium & Exhibition, Dalian, China, Oct. 12-17, 2008.
Yildirim E.D., et.al, “Concurrent Effect of Oxygen-based Plasma Polymerization and Fibronectin Coating of Poly e-caprolactone (PCL) Surface on Osteoblast Cell Attachment and Proliferation”, 8th World Biomaterials Congress, Amsterdam, Holland, May 28, 2008.
Yildirim E.D., et.al, “Effect of Oxygen-Radio Frequency Plasma Treatment on Three-Dimensional Poly (e-Caprolactone) Scaffolds”, Proceedings of the International Manufacturing Science and Engineering , Atlanta, Georgia, October 15-18, 2007.
Yildirim E.D., et.al, “Three Dimensional Composite Alginate/Carbon Nanotube Tissue Scaffolds Printed via Multi-Nozzle Deposition System”, Flexible Automation & Intelligent Manufacturing International Conference (FAIM), Philadelphia, PA, June 16-18, 2007.
Yildirim E.D., et.al, “Enhancement of Early-Time Points Osteoblastic Adhesion on Poly (e-Caprolactone) Scaffolds through Surface Plasma Treatment”, TERMIS North America 2007 Conference and Exposition, Westin Harbour Castle, Toronto, Canada, June 13, 2007.
Yildirim E.D., et.al, “Multi-Nozzle Deposition for Three-Dimensional Printing of Composite Alginate/Carbon Nanotube Tissue Scaffolds”, Proceedings of 17th Solid Freeform Fabrication Symposium, Austin, TX, USA, August 14-16, 2006.
Book Chapters
1. Yildirim E.D., Gandhi M., Fridman A., Guceri S.,Sun W., “Plasma Surface Modification of Three Dimensional Poly (e-Caprolactone) Scaffolds for Tissue Engineering Application” in book titled “Plasma Assisted Decontamination of Biological and Chemical Agents”, Nato Science for Peace and Security Series A: Chemistry and Biology, p: 191-202 , Springer, 2008: ISBN: 1874-6468.
2. Yildirim E.D., Ayan H., Chang R., Sperling M. R., Gorniak R., Guceri S., Sun W., “Assisted Mapping Epileptic Regions of Brain for Invasive Intracranial Electroencephalography” in book titled “Rapid Prototyping Techniques in Medical Applications” from Society of Manufacturing Engineers (SME) (in press).
3. Shor L., Yildirim E.D., Guceri S., and Sun W., “Precision Extruding Deposition for Freeform Fabrication of Poly (ε-Caprolactone) and Poly (ε-Caprolactone)-Hydroxyapatite Tissue Scaffolds”, in book titled “Printed Biomaterials: Rapid Prototyping in Medicine and Surgery”, Editor Roger Narayan and Yuan-Shin Lee, Springer, 2009: ISBN: 978-1-4419-1394-4.
4. Yildirim E.D., Chang R., Guceri S., Sun W., “Biomanufacturing of Polycaprolactone Tissue Scaffolds and Cell-Integrated Tissue Constructs” in book titled “The Handbook of Enabling Technologies for Regenerative Medicine" edited by Drs. James J. Yoo and Anthony Atala, (in press)
1. Yildirim E.D., Gandhi M., Fridman A., Guceri S.,Sun W., “Plasma Surface Modification of Three Dimensional Poly (e-Caprolactone) Scaffolds for Tissue Engineering Application” in book titled “Plasma Assisted Decontamination of Biological and Chemical Agents”, Nato Science for Peace and Security Series A: Chemistry and Biology, p: 191-202 , Springer, 2008: ISBN: 1874-6468.
2. Yildirim E.D., Ayan H., Chang R., Sperling M. R., Gorniak R., Guceri S., Sun W., “Assisted Mapping Epileptic Regions of Brain for Invasive Intracranial Electroencephalography” in book titled “Rapid Prototyping Techniques in Medical Applications” from Society of Manufacturing Engineers (SME) (in press).
3. Shor L., Yildirim E.D., Guceri S., and Sun W., “Precision Extruding Deposition for Freeform Fabrication of Poly (ε-Caprolactone) and Poly (ε-Caprolactone)-Hydroxyapatite Tissue Scaffolds”, in book titled “Printed Biomaterials: Rapid Prototyping in Medicine and Surgery”, Editor Roger Narayan and Yuan-Shin Lee, Springer, 2009: ISBN: 978-1-4419-1394-4.
4. Yildirim E.D., Chang R., Guceri S., Sun W., “Biomanufacturing of Polycaprolactone Tissue Scaffolds and Cell-Integrated Tissue Constructs” in book titled “The Handbook of Enabling Technologies for Regenerative Medicine" edited by Drs. James J. Yoo and Anthony Atala, (in press)
