Scaffold-guided MSK Tissue Engineering
We have synthesized an innovative nanofibrous, yet injectable matrix called PNCOL for musculoskeletal (MSK) tissue regeneration. The PNCOL is synthesized using nanofibrous polycaprolactone (PCL) and collagen type I.
The PNCOL can be used to encapsulate the cells, cytokine and chemokine, and growth factors and proteins for enhanced tissue regeneration and immunomodulaiton.
The PNCOL has been playing an instrumental role in bone, tendon, enthesis, intervertebral disc (IVD) tissue regeneration studies conducted with in vitro and an ex vivo models (organ culturing).
The PNCOL can be used to encapsulate the cells, cytokine and chemokine, and growth factors and proteins for enhanced tissue regeneration and immunomodulaiton.
The PNCOL has been playing an instrumental role in bone, tendon, enthesis, intervertebral disc (IVD) tissue regeneration studies conducted with in vitro and an ex vivo models (organ culturing).
1) (2023) Deciphering the Cell-Specific Effect of Osteoblast-Macrophage Crosstalk in Periodontitis
www.liebertpub.com/doi/abs/10.1089/ten.TEA.2023.0104
2) (2022) Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study
3) (2021) Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold
www.liebertpub.com/doi/abs/10.1089/ten.TEA.2023.0104
2) (2022) Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study
3) (2021) Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold
